SLC39A1
Function
Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into prostate cells (PubMed:12888280).
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Tissue Specificity
Ubiquitous (PubMed:10610721, PubMed:11301334). Expressed in most adult and fetal tissues including the epidermis.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
Alternative names
IRT1, ZIP1, ZIRTL, CGI-08, CGI-71, SLC39A1, Zinc transporter ZIP1, Solute carrier family 39 member 1, Zinc-iron-regulated transporter-like, Zrt- and Irt-like protein 1, ZIP-1, hZIP1