SLC39A10
Function
Zinc-influx transporter (PubMed:17359283, PubMed:27274087, PubMed:30520657). When associated with SLC39A6, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial-to-mesenchymal transition (EMT) (PubMed:23186163). SLC39A10-SLC39A6 heterodimers play also an essentiel role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Plays an important for both mature B-cell maintenance and humoral immune responses (By similarity). When associated with SLC39A10, the heterodimer controls NCAM1 phosphorylation and integration into focal adhesion complexes during EMT (By similarity).
Post-translational modifications
Undergoes N-terminal ectodomain shedding.
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Apical cell membrane
- Multi-pass membrane protein
- Expressed at the apical membranes of proximal tubules in the kidney.
Alternative names
KIAA1265, ZIP10, SLC39A10, Zinc transporter ZIP10, Solute carrier family 39 member 10, Zrt- and Irt-like protein 10, ZIP-10