SLC39A2
Function
Transporter for the divalent cation Zn(2+) (PubMed:10681536, PubMed:29791142, PubMed:30914478). Mediates the influx of Zn(2+) into cells from extracellular space. The Zn(2+) uniporter activity is independent of H(+)-driving force, but is modulated by extracellular pH and membrane potential. Transports also other divalent cations Zn(2+), Cd2(+), Cu2(+), Co2(+) in the order of decreasing affinity, respectively (PubMed:29791142, PubMed:30914478). In the skin, aids in the differentiation of keratinocytes in the epidermis (By similarity).
Sequence Similarities
Belongs to the ZIP transporter (TC 2.A.5) family.
Tissue Specificity
Expressed only in prostate and uterine epithelial cells.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
ZIP2, SLC39A2, Zinc transporter ZIP2, 6A1, Eti-1, Solute carrier family 39 member 2, Zrt- and Irt-like protein 2, ZIP-2, hZIP2