SLC4A8

Function

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:18577713). Plays a major role in pH regulation in neurons (By similarity). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity).

Sequence Similarities

Belongs to the anion exchanger (TC 2.A.31) family.

Tissue Specificity

Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.

Isoform 1

Expressed in the brain.

Isoform 4

Expressed in the brain, heart and kidney.

Isoform 5

Expressed in the brain, heart and kidney.

Cellular localization

• Apical cell membrane
• Multi-pass membrane protein
• Basolateral cell membrane
• Multi-pass membrane protein
• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Multi-pass membrane protein
• Isoform 1
• Cell membrane
• Multi-pass membrane protein
• Isoform 3
• Cell membrane
• Multi-pass membrane protein
• Isoform 4
• Cell membrane
• Multi-pass membrane protein
• Isoform 5
• Cell membrane
• Multi-pass membrane protein

Alternative names

KIAA0739, NBC, NBC3, NDCBE1, SLC4A8, Electroneutral sodium bicarbonate exchanger 1, Electroneutral Na(+)-driven Cl-HCO3 exchanger, Solute carrier family 4 member 8, k-NBC3

Database links

swissprot:Q2Y0W8 omim:605024 entrezGene:9498 swissprot:Q8TC60