Slc5a2
Function
Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (By similarity). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (By similarity). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (PubMed:20616166).
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Tissue Specificity
Expressed in epithelial cells of early proximal tubules (at protein level).
Cellular localization
- Apical cell membrane
- Multi-pass membrane protein
Alternative names
Sglt2, Slc5a2, Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2