SLC5A2
GeneName
SLC5A2
Summary
SLC5A2, also known as SGLT-2 or SGLT2, is a 73 kDa transmembrane protein predominantly expressed in the renal proximal tubules. It functions as a sodium-glucose co-transporter, facilitating the reabsorption of D-glucose and sodium ions from the renal tubular lumen back into the bloodstream. This protein is localised to the apical plasma membrane of epithelial cells and plays a crucial role in glucose homeostasis and renal glucose absorption, contributing to carbohydrate metabolism and sodium ion transport.
Importance
SLC5A2 is relevant to: - Diabetes management, particularly in the context of SGLT-2 inhibitors which are used to lower blood glucose levels in type 2 diabetes patients - Renal physiology, as it is essential for glucose reabsorption in the kidneys - Understanding metabolic disorders, given its role in glucose and sodium transport and their implications in conditions like obesity and hypertension
Top Products
For researchers investigating SLC5A2, we recommend two primary antibodies that cater to different experimental needs. The first is the well-cited polyclonal antibody, Anti-SGLT2 antibody (ab37296), which has garnered 49 citations, reflecting its reliability in Western blotting (WB). This antibody is a trusted choice for those focusing on protein detection in various samples. Additionally, we offer the recombinant antibody, Anti-SGLT2 antibody [EPR29167-46] (ab320086), which is specifically validated for immunohistochemistry (IHC). This recombinant option provides the advantage of batch-to-batch consistency, making it an excellent choice for researchers requiring dependable results in their studies of SLC5A2.
Abcam Product Citation Summary
The SLC5A2 gene, which encodes a sodium-glucose cotransporter, has been studied in various contexts, particularly in relation to kidney function and diabetes. The use of Abcam antibody ab37296 in Western blotting across different species highlights its relevance in understanding the effects of medications like Canagliflozin and the implications of diabetes on cataract development.
Abcam Product Citation Table
Function
Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (PubMed:20980548, PubMed:28592437, PubMed:34880493, PubMed:37217492, PubMed:38057552). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (PubMed:20980548, PubMed:28592437, PubMed:34880493). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (PubMed:37217492). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (By similarity).
Involvement in disease
Renal glucosuria
GLYS
A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Cellular localization
- Apical cell membrane
- Multi-pass membrane protein
Alternative names
SGLT2, SLC5A2, Sodium/glucose cotransporter 2, Na(+)/glucose cotransporter 2, Low affinity sodium-glucose cotransporter, Solute carrier family 5 member 2