SLC5A5
Function
Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:12488351, PubMed:18372236, PubMed:18708479, PubMed:20797386, PubMed:31310151, PubMed:32084174, PubMed:8806637, PubMed:9329364). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:12488351).
Involvement in disease
Thyroid dyshormonogenesis 1
TDH1
A disorder characterized by the inability of the thyroid to maintain a concentration difference of readily exchangeable iodine between the plasma and the thyroid gland, leading to congenital hypothyroidism.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
Tissue Specificity
Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cytoplasm
Alternative names
NIS, SLC5A5, Sodium/iodide cotransporter, Na(+)/I(-) cotransporter, Natrium iodide transporter, Sodium-iodide symporter, Solute carrier family 5 member 5, Na(+)/I(-) symporter