Slc6a1
Function
Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:30270321, PubMed:8420981). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321).
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.
Tissue Specificity
Brain. Expressed in the dentate gyrus of hippocampus, striatum and cerebellum (at protein level).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Presynapse
- Localized at the presynaptic terminals of interneurons.
Alternative names
Gabt1, Gat-1, Gat1, Slc6a1, Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1