SLC6A1

Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:18054861, PubMed:1975955). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (PubMed:18054861, PubMed:21775701). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (PubMed:18054861, PubMed:21775701). Also mediates sodium- and chloride-dependent transport of hypotaurine (By similarity).

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.

Brain.

• Cell membrane
• Multi-pass membrane protein
• Presynapse
• Localized at the presynaptic terminals of interneurons.

Gabt1, Gat-1, Gat1, Slc6a1, Sodium- and chloride-dependent GABA transporter 1, GAT-1, Solute carrier family 6 member 1

• entrezGene:79212
• swissprot:P23978

Proteins

Immunology & Infectious Disease

67001Da