SLC6A12
Function
Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity).
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.
Tissue Specificity
Expressed in kidney, liver, heart, skeletal muscle, placenta, and a widespread distribution in the brain.
Cellular localization
- Basolateral cell membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
- In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane.
Alternative names
BGT1, SLC6A12, Sodium- and chloride-dependent betaine transporter, BGT-1, Na(+)/Cl(-) betaine/GABA transporter, Solute carrier family 6 member 12