Slc6a3 phospho T53
Function
Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1502198, PubMed:1765147, PubMed:1948034, PubMed:1948035, PubMed:8125921). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8125921). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity).
Sequence Similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Tissue Specificity
Brain (PubMed:1765147, PubMed:1948034). Expressed in the substantia nigra and ventral tegmental area, regions that contain dopaminergic cell bodies (PubMed:1765147).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell projection
- Neuron projection
- Cell projection
- Axon
- Localizes to neurite tips in neuronal cells (PubMed:32963038). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity).
Alternative names
Sodium-dependent dopamine transporter, DA transporter, DAT, Solute carrier family 6 member 3, Slc6a3