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SLC7A14

Function

May be involved in arginine transport.

Involvement in disease

Retinitis pigmentosa 68

RP68

A retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

None

The disease is caused by variants affecting the gene represented in this entry.

Sequence similarities

Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.

Tissue specificity

Expressed in skin fibroblasts.

Cellular localization

  • Lysosome membrane
  • Multi-pass membrane protein
  • Exhibits a punctated pattern in the cytoplasm, which partially ovelaps with lysosomes.

Alternative names

  • Probable cationic amino acid transporter
  • Solute carrier family 7 member 14
  • KIAA1613
  • SLC7A14

Target type

Proteins

Molecular weight

84052Da