SLC9A7
Function
Golgi Na(+), K(+)/(H+) antiporter. Mediates the electoneutral influx of Na(+) or K(+) in exchange for H(+). May contribute to the regulation of Golgi apparatus volume and pH.
Involvement in disease
Intellectual developmental disorder, X-linked 108
MRX108
A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Golgi apparatus
- trans-Golgi network membrane
- Multi-pass membrane protein
- Recycling endosome membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
Alternative names
NHE7, SLC9A7, Sodium/hydrogen exchanger 7, Na(+)/H(+) exchanger 7, Solute carrier family 9 member 7, NHE-7