Slco1a1
Function
Mediates the Na(+)-independent transport of organic anions such as steroid sulfate conjugates (dehydroepiandrosterone sulfate (DHEAS), 17-beta-glucuronosyl estradiol, estrone-3-sulfate), conjugated (taurocholate) and unconjugated (cholate) bile acids, prostaglandin E2 (PGE2) and L-thyroxine T4 (PubMed:19129463). Also capable of transporting sulfobromophthalein (BSP), ouabain and gadoxetate (By similarity). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463).
Post-translational modifications
Glycosylated.
Sequence Similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Tissue Specificity
Highly expressed in liver and kidney, and at lower levels in brain, lung, skeletal muscle and proximal colon.
Cellular localization
- Basolateral cell membrane
- Multi-pass membrane protein
Alternative names
Oatp1, Oatp1a1, Slc21a1, Slco1a1, Solute carrier organic anion transporter family member 1A1, Organic anion-transporting polypeptide 1, Sodium-independent organic anion transporter 1, Solute carrier family 21 member 1, OATP-1