SLIT1
Function
Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb.
Tissue Specificity
Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney.
Cellular localization
- Secreted
Alternative names
KIAA0813, MEGF4, SLIL1, SLIT1, Slit homolog 1 protein, Slit-1, Multiple epidermal growth factor-like domains protein 4, Multiple EGF-like domains protein 4