SLMAP
Domain
Alternative spliced transmembrane domains determine subcellular targeting. Isoforms 1, 2, 3 and 4 are targeted to endoplasmic reticulum membrane as well as mitochondrion membrane. Isoform 5 is not targeted to mitochondrion membrane but to endoplasmic reticulum membrane.
Function
Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity).
Sequence Similarities
Belongs to the SLMAP family.
Cellular localization
- Cell membrane
- Sarcolemma
- Single-pass type IV membrane protein
- Cytoplasm
- Myofibril
- Sarcomere
- M line
- Cytoplasm
- Myofibril
- Sarcomere
- Z line
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum (By similarity). Detected along the Z- and M-lines in cardiomyocytes (By similarity).
- Isoform 1
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Mitochondrion membrane
- Single-pass type IV membrane protein
- Isoform 2
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Mitochondrion membrane
- Single-pass type IV membrane protein
- Isoform 3
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Mitochondrion membrane
- Single-pass type IV membrane protein
- Isoform 4
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Mitochondrion membrane
- Single-pass type IV membrane protein
- Isoform 5
- Endoplasmic reticulum membrane
- Single-pass type IV membrane protein
- Do not localize at the mitochondrial membrane.
Alternative names
KIAA1601, SLAP, UNQ1847/PRO3577, SLMAP, Sarcolemmal membrane-associated protein, Sarcolemmal-associated protein