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SMAD5
Function
Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
Post-translational modifications
Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase.
Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
Sequence similarities
Belongs to the dwarfin/SMAD family.
Tissue specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Nucleus
- Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
Alternative names
- Mothers against decapentaplegic homolog 5
- MAD homolog 5
- Mothers against DPP homolog 5
- JV5-1
- SMAD family member 5
- SMAD 5
- Smad5
- hSmad5
- MADH5
- SMAD5
Target type
Proteins
Primary research area
Epigenetics
Other research areas
- Oncology
Molecular weight
52258Da