Small proline-rich protein 2B
Developmental stage
Expressed during differentiation of squamous cells.
Function
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Sequence Similarities
Belongs to the cornifin (SPRR) family.
Tissue Specificity
Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Cellular localization
- Cytoplasm
Alternative names
Small proline-rich protein 2B, SPR-2B, SPRR2B