Smarcd2
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
Post-translational modifications
Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL.
Sequence Similarities
Belongs to the SMARCD family.
Cellular localization
- Nucleus
Alternative names
Baf60b, Smarcd2, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2, 60 kDa BRG-1/Brm-associated factor subunit B, BRG1-associated factor 60B, BAF60B