SMG7
Function
Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
Alternative names
C1orf16, EST1C, KIAA0250, SMG7, Nonsense-mediated mRNA decay factor SMG7, SMG-7 homolog, hSMG-7