SMOC2
Function
Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
Involvement in disease
Dentin dysplasia 1
DTDP1
A dental defect in which both primary and secondary dentitions are affected. The clinical crowns of both permanent and deciduous teeth are of normal shape, form and color in most cases, although they may be slightly opalescent and blue or brown. Teeth may be very mobile and exfoliate spontaneously because of inadequate root formation. On radiographs, the roots are short and may be more pointed than normal. Pulp chambers are usually absent except for a chevron-shaped remnant in the crown. Root canals are usually absent.
None
The disease is caused by variants affecting the gene represented in this entry.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Basement membrane
Alternative names
SMAP2, MSTP117, SMOC2, SPARC-related modular calcium-binding protein 2, Secreted modular calcium-binding protein 2, Smooth muscle-associated protein 2, SMOC-2, SMAP-2