SMOX
Function
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Pathway
Amine and polyamine degradation; spermine degradation.
Sequence Similarities
Belongs to the flavin monoamine oxidase family.
Tissue Specificity
Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
Cellular localization
- Isoform 1
- Cytoplasm
- Nucleus
- Isoform 4
- Cytoplasm
- Nucleus
- Isoform 6
- Cytoplasm
- Nucleus
Alternative names
C20orf16, SMO, UNQ3039/PRO9854, SMOX, Spermine oxidase, Polyamine oxidase 1, PAO-1, PAOh1