SMPDL3B
Function
Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling (By similarity). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (By similarity).
Post-translational modifications
N-glycosylated.
Sequence Similarities
Belongs to the acid sphingomyelinase family.
Cellular localization
- Secreted
- Cell membrane
- Lipid-anchor
- GPI-anchor
Alternative names
ASML3B, ASMLPD, SMPDL3B, Acid sphingomyelinase-like phosphodiesterase 3b, ASM-like phosphodiesterase 3b