SMYD1
Domain
The SET domain is split between the S-sequence (residues 1-49) and the core SET domain (residues 181-258), however the two segments still come together to form a conserved SET domain fold.
Function
Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
Sequence Similarities
Belongs to the class V-like SAM-binding methyltransferase superfamily.
Tissue Specificity
Expression seems mostly restricted to heart and skeletal muscle.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
Histone-lysine N-methyltransferase SMYD1, SET and MYND domain-containing protein 1, SMYD1