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KMT3C / SMYD2

Function

Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Cellular localization

  • Cytoplasm
  • Cytosol
  • Nucleus

Alternative names

KMT3C, SMYD2, N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

49688Da

We found 9 products in 3 categories

Primary Antibodies

Target

Reactive species

Proteins & Peptides

Target

Species of origin

Nature

Cell Lines & Lysates

Target

Cell type

Species or organism