Snap23
Function
Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.
Post-translational modifications
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type A (BoNT/A, botA) which hydrolyzes the 202-Thr-|-Arg-203 bond; the in vitro reaction is not highly efficient (PubMed:9886085).
(Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type E (BoNT/E) which hydrolyzes the 185-Arg-|-Ile-186 bond; the in vitro reaction is more efficient than that of BoNT/A (PubMed:9886085).
Sequence Similarities
Belongs to the SNAP-25 family.
Tissue Specificity
Expressed in non-neuronal tissues.
Cellular localization
- Cell membrane
- Peripheral membrane protein
- Cell membrane
- Lipid-anchor
- Synapse
- Synaptosome
- Mainly localized to the plasma membrane.
Alternative names
Sndt, Synaptosomal-associated protein 23, SNAP-23, Syndet, Vesicle-membrane fusion protein SNAP-23