Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
Belongs to the synuclein family.
Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
Proteins
Neuroscience
14288Da
We found 16 products in 3 categories
ab167607
ab53726
ab307306
Anti-alpha + beta Synuclein antibody [EPR1646-65] - BSA and Azide free (Detector)