SNCG
Function
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Post-translational modifications
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
Sequence Similarities
Belongs to the synuclein family.
Tissue Specificity
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung.
Cellular localization
- Cytoplasm
- Perinuclear region
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Centrosome
- Cytoplasm
- Cytoskeleton
- Spindle
- Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
Alternative names
BCSG1, PERSYN, PRSN, SNCG, Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR