SNRNP70
Domain
The RRM domain mediates interaction with U1 RNA.
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158).
Isoform 3
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Isoform 4
Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.
Post-translational modifications
The N-terminus is blocked.
Extensively phosphorylated on serine residues in the C-terminal region.
Cellular localization
- Nucleus speckle
- Nucleus
- Nucleoplasm
- Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.
Alternative names
RNPU1Z, RPU1, SNRP70, U1AP1, SNRNP70, U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70