U1 small nuclear ribonucleoprotein 70 kDa

The RRM domain mediates interaction with U1 RNA.

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:19325628, PubMed:2467746, PubMed:25555158).

Isoform 3

Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Isoform 4

Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

The N-terminus is blocked.

Extensively phosphorylated on serine residues in the C-terminal region.

• Nucleus speckle
• Nucleus
• Nucleoplasm
• Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.

RNPU1Z, RPU1, SNRP70, U1AP1, SNRNP70, U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, U1-70K, snRNP70

• entrezGene:6625
• omim:180740
• swissprot:P08621

Proteins

Epigenetics

51557Da