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SNRNP70

OverviewProducts

Domain

The RRM domain mediates interaction with U1 RNA.

Function

Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome (PubMed:19325628, PubMed:25555158). SNRNP70 binds to the loop I region of U1-snRNA (PubMed:2467746, PubMed:19325628, PubMed:25555158).

Isoform 3

Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Isoform 4

Truncated isoforms that lack the RRM domain cannot bind U1-snRNA.

Post-translational modifications

The N-terminus is blocked.

Extensively phosphorylated on serine residues in the C-terminal region.

Cellular localization

  • Nucleus speckle
  • Nucleus
  • Nucleoplasm
  • Colocalizes with SCNM1 and LUC7L2 in nuclear speckles.

Alternative names

  • U1 small nuclear ribonucleoprotein 70 kDa
  • U1 snRNP 70 kDa
  • U1-70K
  • snRNP70
  • U1AP1
  • SNRP70
  • RPU1
  • SNRNP70
  • RNPU1Z

Database links

Target type

Proteins

Molecular weight

51557Da