Snrpc
Developmental stage
First detected in the testis 18 days after birth. Levels increase successively between days 21-28. On day 42, levels decrease.
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.
Sequence Similarities
Belongs to the U1 small nuclear ribonucleoprotein C family.
Tissue Specificity
Widely expressed. In the testis, expressed in somatic and germinal testicular cells but not in elongated spermatids.
Cellular localization
- Nucleus
Alternative names
Snrp1c, U1 small nuclear ribonucleoprotein C, U1 snRNP C, U1-C, U1C