SNTB1
Domain
The PH 1 domain mediates the oligomerization in a calcium dependent manner.
The PDZ domain binds to the last three or four amino acids of ion channels and receptor proteins. The association with dystrophin or related proteins probably leaves the PDZ domain available to recruit proteins to the membrane (By similarity).
The SU domain binds calmodulin in a calcium-dependent manner.
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of membrane proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Post-translational modifications
Phosphorylated by CaM-kinase II.
Sequence Similarities
Belongs to the syntrophin family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cell membrane
- Sarcolemma
- Peripheral membrane protein
- Cytoplasmic side
- Cell junction
- Cytoplasm
- Cytoskeleton
- In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane and at neuromuscular junctions.
Alternative names
SNT2B1, SNTB1, Beta-1-syntrophin, 59 kDa dystrophin-associated protein A1 basic component 1, BSYN2, Syntrophin-2, Tax interaction protein 43, DAPA1B, TIP-43