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SNX16

OverviewProducts

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

Function

May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.

Sequence similarities

Belongs to the sorting nexin family.

Tissue specificity

Detected in placenta, lung, liver,heart and pancreas.

Cellular localization

  • Early endosome membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Late endosome membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cytoplasm
  • Lysosome

Alternative names

  • Sorting nexin-16
  • SNX16

Database links

Target type

Proteins

Molecular weight

39167Da