SNX16
Domain
The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.
Function
May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm.
Sequence Similarities
Belongs to the sorting nexin family.
Tissue Specificity
Detected in placenta, lung, liver,heart and pancreas.
Cellular localization
- Early endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Late endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cytoplasm
- Lysosome
Alternative names
Sorting nexin-16, SNX16