SNX33

The PX and BAR domains mediate association with membranes and are required for membrane tubulation.

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

Phosphorylated.

Belongs to the sorting nexin family.

Detected in heart and pancreas.

• Cytoplasm
• Cytosol
• Membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cytoplasmic vesicle membrane
• Peripheral membrane protein
• Cytoplasmic side
• Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941).

SH3PX3, SH3PXD3C, SNX30, SNX33, Sorting nexin-33, SH3 and PX domain-containing protein 3

• entrezGene:257364
• swissprot:Q8WV41

Proteins

Neuroscience

65265Da