Skip to main content

SH3PX1/SNX9

OverviewProducts

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.

Function

Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F-actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.

Post-translational modifications

Ubiquitinated by ITCH.

Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.

Sequence similarities

Belongs to the sorting nexin family.

Tissue specificity

Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes.

Cellular localization

  • Cytoplasmic vesicle membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cell membrane
  • Peripheral membrane protein
  • Cytoplasmic side
  • Cytoplasmic vesicle
  • Clathrin-coated vesicle
  • Golgi apparatus
  • Trans-Golgi network
  • Cell projection
  • Ruffle
  • Cytoplasm
  • Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.

Alternative names

  • Sorting nexin-9
  • SH3 and PX domain-containing protein 1
  • SH3 and PX domain-containing protein 3A
  • Protein SDP1
  • SH3PX1
  • SH3PXD3A
  • SNX9

Database links

Target type

Proteins

Molecular weight

66592Da