SOCS5

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.

Protein modification; protein ubiquitination.

Phosphorylated. Phosphorylation is induced by EGF.

CIS6, CISH5, CISH6, KIAA0671, SOCS5, Suppressor of cytokine signaling 5, SOCS-5, Cytokine-inducible SH2 protein 6, Cytokine-inducible SH2-containing protein 5, CIS-6

• entrezGene:9655
• omim:607094
• swissprot:O75159

Proteins

Oncology

61246Da