SOCS6
Domain
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
Pathway
Protein modification; protein ubiquitination.
Alternative names
CIS4, SOCS4, SOCS6, Suppressor of cytokine signaling 6, SOCS-6, Cytokine-inducible SH2 protein 4, Suppressor of cytokine signaling 4, CIS-4, SOCS-4