SORBS1
Function
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions (By similarity).
Post-translational modifications
O-glycosylated.
Tissue Specificity
Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
Cellular localization
- Cell junction
- Adherens junction
- Cell membrane
- Cytoplasm
- Cytoskeleton
- Cell junction
- Focal adhesion
- Nucleus
- Nucleus matrix
- Colocalizes with the Ten-1 ICD form of TENM1 in the nucleus (By similarity). Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.
Alternative names
KIAA0894, KIAA1296, SH3D5, SORBS1, Sorbin and SH3 domain-containing protein 1, Ponsin, SH3 domain protein 5, SH3P12, c-Cbl-associated protein, CAP