SORBS3
Function
Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
Post-translational modifications
Phosphorylated at Ser-530 by MAPK1/ERK2 during cell spreading.
Tissue Specificity
Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
Cellular localization
- Isoform Alpha
- Cell junction
- Cytoplasm
- Cytoskeleton
- Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites.
- Isoform Beta
- Cell junction
- Nucleus
- Cytoplasm
- Cytoskeleton
- Localized at cell-extracellular matrix junctions (By similarity). Both isoforms were localized at focal adhesion and cell-cell adhesion sites, vinexin beta was also found in the nucleus.
Alternative names
SCAM1, SORBS3, Vinexin, SH3-containing adapter molecule 1, Sorbin and SH3 domain-containing protein 3, SCAM-1