Sororin
Domain
The KEN box is required for the association with the APC/C complex.
Function
Regulator of sister chromatid cohesion in mitosis stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair.
Post-translational modifications
Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5.
Ubiquitinated by the APC/C complex in G1, leading to its degradation.
Sequence Similarities
Belongs to the sororin family.
Cellular localization
- Nucleus
- Chromosome
- Cytoplasm
- Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
Alternative names
Sororin, Cell division cycle-associated protein 5, p35, CDCA5