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SOSTDC1

Function

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling (By similarity). Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.

Sequence Similarities

Belongs to the sclerostin family.

Tissue Specificity

Highly expressed in kidney and weakly in lung.

Cellular localization

Alternative names

USAG1, CDA019, SOSTDC1, Sclerostin domain-containing protein 1, Ectodermal BMP inhibitor, Uterine sensitization-associated gene 1 protein, Ectodin, USAG-1

swissprot:Q6X4U4 entrezGene:25928 omim:609675