Expressed in the basal cells of the tongue epithelium at birth until P20 (PubMed:32758484). Expressed in the suprabasal cells of the buccal mucosa and esophagus at P20 (PubMed:32758484).
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Transcription factor that forms a trimeric complex with POU5F1 (OCT3/4) on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (PubMed:15863505, PubMed:17097055, PubMed:19740739, PubMed:32703285). Binds to the proximal enhancer region of NANOG (PubMed:15863505). Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (PubMed:22198669). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
Methylation at Lys-44 and Lys-119 is necessary for the regulation of SOX2 proteasomal degradation.
Ubiquitinated by WWP2, leading to proteasomal degradation.
Expressed in the cochlea (at protein level) (PubMed:32127020). Expressed in the brain and retina (PubMed:15863505, PubMed:7590241). A very low level of expression is seen in the stomach and lung (PubMed:15863505, PubMed:7590241). Expressed in the kidney (PubMed:15863505).
Proteins
Neuroscience
34454Da
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