SOX8

Domain

The transactivation domains TAM and TAC (for transactivation domain in the middle and at the C-terminus, respectively) are required to contact transcriptional coactivators and basal transcriptional machinery components and thereby induce gene transactivation.

The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.

Function

Transcription factor that may play a role in central nervous system, limb and facial development. May be involved in male sex determination. Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.

Tissue Specificity

Widely expressed in the embryo.

Cellular localization

• Nucleus

Alternative names

Transcription factor SOX-8, SOX8

Database links

swissprot:P57074 swissprot:Q9W757 entrezGene:395483 entrezGene:395573

Other research areas

• Immuno-oncology