Sp7
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function
Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056).
Post-translational modifications
Propionylated (PubMed:30026585). Depropionylation at Lys-368 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts (PubMed:30026585).
Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours (By similarity).
Sequence Similarities
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Tissue Specificity
Osteoblast/chondrocyte specific.
Cellular localization
- Nucleus
Alternative names
Osx, Sp7, Transcription factor Sp7, C22, Zinc finger protein osterix