SP8
Domain
The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.
Function
Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).
Sequence Similarities
Belongs to the Sp1 C2H2-type zinc-finger protein family.
Cellular localization
- Nucleus
Alternative names
Transcription factor Sp8, Specificity protein 8, SP8