SPACA1
Function
Plays a role in acrosome formation and establishment of normal sperm morphology during spermatogenesis (PubMed:34172998). Important for male fertility (PubMed:11870081).
Involvement in disease
Spermatogenic failure 85
SPGF85
An autosomal recessive male infertility disorder characterized by globozoospermia and reduced progressive sperm motility.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
N-glycosylated.
Tissue Specificity
Testis specific.
Cellular localization
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome inner membrane
- Single-pass type I membrane protein
- Primarily found in the equatorial segment of the acrosome (PubMed:11870081). The tyrosine phosphorylated protein localizes to a smaller region within the equatorial segment (By similarity). Also expressed weakly in the principal segment (PubMed:11870081).
Alternative names
SAMP32, SPACA1, Sperm acrosome membrane-associated protein 1, Sperm acrosomal membrane-associated protein 32