PU.1/Spi1

Function

Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing (By similarity).

Sequence similarities

Belongs to the ETS family.

Cellular localization

• Nucleus

Alternative names

• Transcription factor PU.1
• 31 kDa-transforming protein
• SPI1

Database links

• entrezGene:6688
• omim:165170
• swissprot:P17947

Target type

Proteins

Primary research area

Epigenetics

Molecular weight

31083Da