SPINDOC

Negatively regulates the transcriptional activator activity of SPIN1 via inhibition of its histone methyl-binding ability (PubMed:29061846). Represses the expression of a number of SPIN1-regulated genes and the SPIN1-mediated activation of the Wnt signaling pathway (PubMed:29061846). Can also inhibit the histone methyl-binding abilities of SPIN2A, SPIN2B, SPIN3 and SPIN4 (PubMed:29061846). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed:34737271).

• Nucleus
• Chromosome
• Colocalizes with PARP1 to sites of DNA damage.

C11orf84, SPINDOC, Spindlin interactor and repressor of chromatin-binding protein, SPIN1-docking protein, SPIN-DOC

• entrezGene:144097
• swissprot:Q9BUA3

Proteins

41037Da