SPINK1
Function
Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:7142173). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (By similarity).
In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Involvement in disease
Pancreatitis, hereditary
PCTT
A disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Tropical calcific pancreatitis
TCP
Idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Cellular localization
- Secreted
Alternative names
PSTI, SPINK1, Serine protease inhibitor Kazal-type 1, Pancreatic secretory trypsin inhibitor, Tumor-associated trypsin inhibitor, TATI