SPINK2
Function
As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects (PubMed:28554943). May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.
Involvement in disease
Spermatogenic failure 29
SPGF29
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia or oligozoospermia. When produced, spermatozoa are immotile and have abnormal morphology, primarily defects of the acrosome and head-neck junction.
None
The disease is caused by variants affecting the gene represented in this entry.
Tissue Specificity
Expressed in epididymis (at protein level).
Cellular localization
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
Alternative names
Serine protease inhibitor Kazal-type 2, Acrosin-trypsin inhibitor, Epididymis tissue protein Li 172, HUSI-II, SPINK2