Component of a topoisomerase 6 complex specifically required for meiotic recombination. Together with TOP6BL, mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination. The complex promotes relaxation of negative and positive supercoiled DNA and DNA decatenation through cleavage and ligation cycles. Essential for the phosphorylation of SMC3, HORMAD1 and HORMAD2.
Belongs to the TOP6A family.
Highly expressed in testis.
Meiotic recombination protein SPO11, Cancer/testis antigen 35, CT35
Proteins
We found 1 product in 1 category